Bordetella pertussis Lipid A Glucosamine Modification Confers Resistance to Cationic
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چکیده
Bordetella pertussis Lipid A Glucosamine Modification Confers Resistance to Cationic 1 Antimicrobial Peptides and Increases Resistance to Outer Membrane Perturbation 2 3 4 5 Nita R. Shah, Robert E. W. Hancock, Rachel C. Fernandez# 6 7 Department of Microbiology and Immunology, The University of British Columbia, Vancouver, 8 Canada, V6T 1Z3 9 10 Running Title: Modified B. pertussis Lipid A Confers CAMP Resistance 11 12 13 # Address correspondence to Rachel C. Fernandez, [email protected]. 14 15 16 17 18 19 AAC Accepts, published online ahead of print on 27 May 2014 Antimicrob. Agents Chemother. doi:10.1128/AAC.02590-14 Copyright © 2014, American Society for Microbiology. All Rights Reserved.
منابع مشابه
Bordetella pertussis lipid A glucosamine modification confers resistance to cationic antimicrobial peptides and increases resistance to outer membrane perturbation.
Bordetella pertussis, the causative agent of whooping cough, has many strategies for evading the human immune system. Lipopolysaccharide (LPS) is an important Gram-negative bacterial surface structure that activates the immune system via Toll-like receptor 4 and enables susceptibility to cationic antimicrobial peptides (CAMPs). We show modification of the lipid A region of LPS with glucosamine ...
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